And widely used
Research findings show that the level of IGFBP-1 in amniotic fluid increases significantly in early pregnancy and remains high throughout. The Actim PROM test can, therefore, be used since the early stages of pregnancy.
The test has been evaluated in several independent studies around the world. All of them have constantly proven that it is an extremely specific and sensitive method to detect premature rupture of fetal membranes. Therefore Actim PROM provides results you can always rely on.
Evalution studies on the Actim PROM test as a method to detect premature rupture of fetal membranes
Publication
Number
of patients
Gestation
age (wk)
End-point
Sensitivity
Specificity
NPV
PPV
Rutanen et. al. 1996
130
15-17
Clinical Confirmation
100%
94.7%
100%
93.2%
Ragosch et. al. 1996
75
22-41
Clinical Confirmation
100%
72.4
100%
83%
Jain et. al. 1998
100
24-42
Clinical Confirmation
100%
89%
100%
75%
71
31.9+5.3
Clinical Confirmation
97%
97%
97%
97%
Kubota et. al. 1998
48
15-41
Clinical Confirmation
94.7%
93.1%
NWA
NWA
Actim PROM is a highly specific and sensitive method to detect a membrane rupture.
