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Actim Prom
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Premature rupture of fetal membranes (PROM) is a serious pregnancy complication that causes approximately one third of premature deliveries. Prematurity increases the risk of perinatal morbidity and mortality.

References
Rutanen.
Insulin-like growth factors in obstetrics. Curr Opin Obstet Gynecol (2000) 12:163-168

Guibourdenche et. al.
Rapid detection of insulin-like growth factor-binding protein-1 and foetal fibronectin in cervico-vaginal secretions to diagnose premature membrane rupture. Ann Clin Biochem (1999) 36: 388-390.

Kubota and Takeuchi.
Evaluation of Insulin-like Growth Factor Binding Protein-1 as diagnostic tool for rupture of membranes. J Obstet Gynaecol Res (1998) 24:411-417.

Darj and Lyrenas.
Insulin-like growth factor binding protein-1, a quick way to detect amniotic fluid. Acta Obstet Gynecol Scand (1998) 77: 295-297.

Jain and Morris.
A clinical study to evaluate the usefulness of the MAST test in diagnosing pre-labour rupture of membranes. J Obstet Gynecol (1998) 18:33-36.

Paternoster et. al.
Insulin-like growth factor protein test (IGFBP-1) in predicting preterm delivery. Labor and delivery. The Proceedings of the 2nd World Congress on Labor and Delivery. May 1997, Rome Italy.

Ragosch et. al.
Insulin like growth factor binding protein 1 (IGFBP-1) und fetales Fibronectin in der Diagnostik eines vorzeitigen Blasensprunges. Geburts u. Frauenheilk (1996) 56:1-6

Rutanen et. al.
Evaluation of a rapid strip test for insulin-like growth factor binding protein-1 in the diagnosis of ruptured fetal membranes. Clinica Chimica Acta (1996) 253:91-101.

Rutanen et. al.
Measurement of insulin-like growth factor binding protein-1 in cervical/vaginal secretions: comparison with the ROM-check Membrane Immunoassay in the diagnosis of ruptured fetal membranes. Clinica Chimica Acta (1993) 214:73-81.

Wathen et. al.
Levels of insulin-like growth factor-binding protein-1 increase rapidly in amniotic fluid from 11 to 16 weeks of pregnancy. J Endocrinol (1993) 137:R1-R